2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-132857
    ZXH-4-130 2711006-66-3 98%
    ZXH-4-130 is a highly potent and selective degrader of CRBN. ZXH-4-130 is a CRBN-VHL compound (hetero-PROTAC).
    ZXH-4-130
  • HY-132903
    eeAChE-IN-1 2763366-27-2 98%
    eeAChE-IN-1 is a potent eeAChE inhibitor with an IC50 value of 23 nM.
    eeAChE-IN-1
  • HY-132904
    eeAChE-IN-2 2763366-33-0 98%
    eeAChE-IN-2 is a potent eeAChE inhibitor with an IC50 value of 2 nM.
    eeAChE-IN-2
  • HY-13295S
    Vinpocetine-d5 2734920-39-7 98%
    Vinpocetine-d5 is the deuterium labeled Vinpocetine. Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na+ channels. The IC50 value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders.
    Vinpocetine-d5
  • HY-133112
    7-Desmethyl-3-hydroxyagomelatine 166527-00-0 98%
    7-Desmethyl-3-hydroxyagomelatine (3-Hydroxy-7-desmethyl agomelatine), a metabolite of Agomelatine, has less activity than Agomelatine. Agomelatine is a melatonergic (MT1 and MT2) agonist and serotonergic (5HT2C) antagonist.
    7-Desmethyl-3-hydroxyagomelatine
  • HY-133115
    N-Desmethylnefopam 46868-19-3 98%
    N-Desmethylnefopam is the main metabolite of Nefopam. N-Desmethylnefopam is a centrally-acting but non-opioid analgesic agent, for the relief of moderate to severe pain. Nefopam targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo.
    N-Desmethylnefopam
  • HY-133160
    Valproic acid hydroxamate 106132-78-9 98%
    Valproic acid hydroxamate (VPA-HA) has shown anticonvulsant activity in a mouse neural tube defect model, without any teratogenic effects.
    Valproic acid hydroxamate
  • HY-133171
    (R)-Norfluoxetine 130194-43-3 98%
    (R)-Norfluoxetine is the (R)-enantiomer of Norfluoxetine (HY-135556). (R)-Norfluoxetine is a potent serotonin re-uptake inhibitor, with a Ki of 13 nM. (R)-Norfluoxetine can be used for the research of depression.
    (R)-Norfluoxetine
  • HY-133185
    Megastigmatrienone (mixed isomers) 13215-88-8 98%
    Megastigmatrienone (mixed isomers) is a mixture of isomers of Megastigmatrienone, a compound that has the aroma of tobacco.
    Megastigmatrienone (mixed isomers)
  • HY-133195
    Nefopam 13669-70-0 98%
    Nefopam (Fenazoxine) is an orally active, non-opioid and non-steroidal centrally acting analgesic agent. Nefopam blocks voltage-sensitive sodium channels (IC50=27 μM) and modulates glutamatergic transmission in rodents. Nefopam can be used in studies of neuropathic pain, anticonvulsant, as well as the prevention of postoperative shivering and hiccups.
    Nefopam
  • HY-133528
    OptoBI-1 2415272-11-4 98%
    OptoBI-1 is a photochromic TRPC3 agonist, which asts as a photopharmacological tool to control of neuronal firing.
    OptoBI-1
  • HY-133533
    O-2050 1883545-42-3 98%
    O-2050 is a high affinity cannabinoid CB1 receptor antagonist with a Ki of 2.5 nM. O-2050 inhibits cannabinoid CB2 receptor (Ki=0.2 nM). O-2050 can cause locomotor stimulation in mice.
    O-2050
  • HY-133596
    12,14-Dichlorodehydroabietic acid 65281-77-8 98%
    12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, is a potent Ca2+-activated K+ (BK) channel opener. 12,14-Dichlorodehydroabietic acid blocks GABA-dependent chloride entry in mammalian brain and operates as a non-competitive GABAA antagonist. 12,14-Dichlorodehydroabietic acid increases cytosolic free Ca2+ and stimulates transmitter release.
    12,14-Dichlorodehydroabietic acid
  • HY-133732
    Alaproclate hydrochloride 60719-83-7 98%
    Alaproclate (GEA 654) hydrochloride is a selective and orally active serotonin re-uptake inhibitor (SSRI). Alaproclate hydrochloride also acts as a potent, reversible and noncompetitive antagonist of the NMDA receptor coupled ion flow.
    Alaproclate hydrochloride
  • HY-133773
    Desoxochlordiazepoxide 4393-72-0 98%
    Desoxochlordiazepoxide is a kind of benzodiazepine compound. Desoxochlordiazepoxide has anticonvulsant effect.
    Desoxochlordiazepoxide
  • HY-133797
    Cyclobenzaprine N-oxide 6682-26-4 98%
    Cyclobenzaprine N-oxide is the tertiary amine metabolite of Cyclobenzaprine (HY-B0740) in liver particles. Cyclobenzaprine is a skeletal muscle relaxant and is active on the central nervous system. The liver cytosol from liver particles has reductase activity that can reduce Cyclobenzaprine N-oxide to the corresponding amine.
    Cyclobenzaprine N-oxide
  • HY-133832
    Elopiprazole 115464-77-2 98%
    Elopiprazole can be used in study of neurological disease and SARS-CoV-2.
    Elopiprazole
  • HY-133858
    25N-NBOMe hydrochloride 1566571-65-0 98%
    25N-NBOMe hydrochloride, a 2C-N derivative, is a 5-HT2A and 5-HT2C receptors agonist with Ki values of 0.144 nM and 1.06 nM, respectively. 25N-NBOMe hydrochloride has little to no efficacy at inducing release of preloaded neurotransmitter from recombinant dopamine, serotonin and norepinephrine transporters.
    25N-NBOMe hydrochloride
  • HY-133935
    Benaxibine 27661-27-4 98%
    Benaxibine is an alkaloid belonging to the quinolone family of compounds. Benaxibine has a variety of biological activities, including anti-inflammatory, antioxidant, anti-tumor and immune-enhancing effects. Benaxibine can be used for screening and research of diseases such as inflammation and tumor.
    Benaxibine
  • HY-133956
    3-ATA 129821-08-5 98%
    3-ATA (NSC 680434) is a selective inhibitor of cyclin-dependent kinase 4 (CDK4) with neuroprotective and antitumor effects. 3-ATA can alleviate kainic acid (HY-N2309)-induced apoptosis in cerebellar granule neurons, which can be used in the study of neurodegenerative diseases.
    3-ATA
Cat. No. Product Name / Synonyms Application Reactivity